We are pleased to introduce this new bioactive scalp care ingredient from Syensqo. Upcycled from coffee grounds and designed using AI-guided peptide technology, it is formulated to deliver soothing, hydration and anti-hair loss benefits.
Scalp care is one of the fastest-growing segments in personal care, as consumers are increasingly recognising that a healthy scalp is the foundation for healthy hair and brands are applying skincare principles and ingredients to scalp products. There is also rising concern around pollution, stress and ageing, leading people to look for holistic scalp care solutions that go beyond basic cleansing.
For formulators, this is a significant opportunity, and Re2 Coffea Arabica Peptide is designed to help you make the most of it.
About Re2 Coffea Arabica Peptide
Re2 Coffea Arabica Peptide is a scalp care active peptide that delivers targeted soothing and enhances hydration while reducing inflammation, redness, and hair loss. Upcycled from coffee grounds, its amino acid profile is AI-predicted and enzymatically released to maximize efficacy, with scientifically validated claims.
AI-guided peptide prediction is combined with molecular docking simulation, which means that peptide sequences were identified to specifically target key scalp biomarkers associated with hydration, softness, TEWL reduction, redness, and anti-inflammatory benefits. This innovative approach ensures both efficacy and transparency, addressing the growing demand for scientifically validated, high-performance scalp care solutions.
Re2 Coffea Arabica Peptide is derived from coffee grounds from a Rainforest Alliance-certified plantation in Pu’er, Yunnan, which has over 30 years of cultivation experience and a strong commitment to reducing water use, protecting wildlife habitats and minimising waste. The result is a high natural origin index (ISO 16128:2, Ino = 1.00) and a compelling sustainability story.
Re2 Coffea Arabica Peptide is water soluble and straightforward to incorporate into most aqueous systems.
INCI Name: Water, Butylene Glycol, Coffea Arabica (Coffee) Seed Extract, 1,2-Hexanediol, Hydroxyacetophenone
Key Benefits:
- Scalp soothing: reduces inflammation, redness, stinging, itching, tightness and burning sensation
- Barrier reinforcement: significantly improves scalp barrier function (TEWL reduction)
- Hydration: measurable increase in scalp moisture content
- Scalp softness: improved pliability and comfort
- Anti-hair loss: reduction in hair shedding vs. placebo
- Hair fibre benefits: improvements in smoothness, frizz control and ease of detangling
- Upcycled and sustainable: fully traceable, Rainforest Alliance-certified source; natural origin index of 1.00
- AI-driven technology: targeted peptide design validated through molecular docking
Testing & Clinical Data
In vitro: anti-inflammatory efficacy (keratinocytes)
Re2 Coffea Arabica Peptide demonstrated significant reductions in key inflammatory biomarkers following SLS challenge at 0.01% concentration: approximately 50% reduction in IL-1α, 70% reduction in TNF-α and 90% reduction in PGE2. This is a similar performance to Dexamethasone in reducing the level of inflammatory biomarkers.
Clinical study: scalp barrier and hydration (28-day)
A 28-day clinical study involving 44 volunteers with sensitive scalps and weakened barrier function (TEWL >15 g/h/m²) tested a shampoo formulation containing 2% Re2 Coffea Arabica Peptide against placebo.
Results at Day 28:
| Parameter | Result vs Placebo |
| Scalp barrier (TEWL reduction) | +133% improvement |
| Scalp hydration | +37% improvement |
| Scalp softness | +54% improvement |
| Scalp redness | -33% improvement |
| Hair loss count | -81% improvement |
Volunteers also reported significant reductions in scalp sting, tightness, itching, pain and burning sensation at both Day 14 and Day 28.
As well as scalp improvements, Re2 Coffea Arabica Peptide significantly improved hair fibres, showing a 72% improvement in hair smoothness, a 25% improvement in ease of detangling and a 52% improvement in frizz control.
Applications
Re2 Coffea Arabica Peptide is suitable for a wide range of rinse-off and leave-on hair care formats:
- Shampoos (including sensitive scalp and anti-hair loss)
- Leave-on and rinse-off conditioners
- Scalp serums and treatments
- Hair masks
- Styling products
If you’d like to request a sample of Re2 Coffea Arabica Peptide or discuss how it could work in your formulations, please get in touch with the HARKE UK & Ireland team.
