At HARKE Pharma, we source reliable, pharmaceutical grade excipients that help our customers formulate safely and efficiently. Preventol® CMK PG from LANXESS is one of those proven workhorses, a high-quality preservative with broad antimicrobial properties that’s been used for decades across pharma and healthcare.
Preventol® CMK PG
INCI: Chlorocresol (P-Chloro-M-Cresol)
A highly purified form of chlorocresol, Preventol® CMK PG is offered as a preservative for pharmaceutical applications including medical salves and vaccines, and has been tested to align with British, European and US pharmacopoeias.
Why formulators choose Preventol® CMK PG
- Broad spectrum protection: Effective against Gram-positive and Gram-negative bacteria, as well as yeasts and moulds, making it ideal for multi-modal spoilage risks.
- Proven track record in pharma: Chlorocresol is a well-known disinfectant/antiseptic and preservative used in medicinal products for humans and animals.
- Pharmacopoeia orientation: Preventol® CMK PG is specifically positioned by Lanxess for pharmaceutical applications, supporting compliance-minded development.
- Formulation-friendly: Compatible with anionic surfactants, non-ionic surfactants, and emulsifiers, while also exhibiting a synergistic effect with other antiseptics and bactericides.
- Safe and sustainable choice: Formaldehyde-free, no toxic impurities, and readily biodegradable.
Efficacy data: Minimal Inhibition Concentration (MIC) values
The following MIC values highlight the broad antimicrobial activity of Preventol® CMK PG, demonstrating effectiveness against a range of bacteria and fungi relevant to pharmaceutical formulations.
Against bacteria
| Organism | MIC (ppm) |
| Alcaligenes faecalis ATCC 35655 | 250 |
| Bacillus subtilis ATCC 6633 | 500 |
| Corynebacterium ammoniagenes ATCC
6871 |
500 |
| Escherichia coli ATCC 10536 | 250 |
| Pseudomonas aeruginosa ATCC 15442 | 500 |
| Staphylococcus aureus ATCC 6538 | 250 – 500 |
Against Fungi
| Organism | MIC (ppm) |
| Aspergillus niger DSM 2143 | 250 |
| Chaetomium globosum ATCC 6205 | 50 – 100 |
| Geotrichum candidum CMI 321760 | 175 – 250 |
| Rhodotorula mucilaginosa DSM 13621 | 250 – 500 |
| Stachybotrys chartarum ATCC 16026 | 50 |
Typical applications in pharmaceuticals
- Topical dosage forms (creams, ointments, gels): Helps control a wide spectrum of microbes in water-containing systems at concentrations of up to 0.1%.
- Vaccines: Applied as a preservative for stability and safety, typically at concentrations of up to 0.1%.
- Aqueous suspensions & emulsions: Useful where both bacterial and fungal challenges are expected over shelf-life.
- Human and veterinary health products: Recognised antimicrobial/antiseptic with preservative use in medicinal products.
Storage & shelf life recommendations
- Shelf life: At least 24 months when correctly stored in the original, sealed container.
- Conditions: Store dark and dry, away from air, light, moisture and heat.
Getting started with Preventol® CMK PG
Want to learn more about Preventol® CMK PG, receive tailored formulation advice or get a sample to test? Contact the team at HARKE Pharma today – we look forward to hearing from you!
