HarkePlus RemindPro: Proven to Boost Total Memory by up to 10.1%

HarkePlus RemindPro – FOS + L-theanine is a patented nutraceutical compound containing fructooligosaccharides and L-theanine that has been proven to boost total memory by up to 10.1% within just 30-days use.

HarkePlus RemindPro is the combination of two plant-derived natural products for human memory and cognition; fructooligosaccharides (FOS) from Morinda officinalis and L-theanine from Camellia sinensis. A study has shown that this synergistic complex has been clinically proven to boost memory and cognition. The compound can be used in supplements, as well as in food and beverage applications.

What are fructooligosaccharides?

Fructooligosaccharides are non-digestible short chain carbohydrates which occur naturally in many plants. Because fructooligosaccharides are non-digestible they reach the large intestine intact where they can deliver a prebiotic effect. 

What is L-theanine?

L-theanine is an amino acid found in green tea. It is commonly used in supplements and has benefits reported for cognitive health, increased focus and a reduction in stress and anxiety.

 

Benefits of HarkePlus RemindPro 

A study has shown benefits in the following areas:

  • Improvement in associated learning
  • Improvement in graphic memory
  • Improvement in memory quotient
  • Improvement in recognition of meaningless image
  • Improvement in direct memory
  • Improvement in portrait retrieval

Supporting Study Results

The results below show how administration of FOS and L-theanine enhanced adult memory in a clinical trial. ** indicates p < .01 versus before trial, ## indicates p < .01 versus placebo group. 

Figure (a) shows the measurement of selected aspects of memory in the treatment group before and after trial, whilst figure (b) shows the measurement of selected aspects of memory in the placebo group before and after trial. Figure (c) shows measurement of selected aspects of memory in-between placebo and treatment group after trial, whilst (d) shows total memory and memory quotient between placebo and treatment group after trial. 

Source: Li, Y., Jiang, Y., Zhang, Z., Loake, V. I. P., Bao, X., & Loake, G. J. (2024). Improvement of both human and animal memory by synergy between fructooligosaccharide and L- theanine function establishing a safe and effective food supplement. Food Science & Nutrition, 00, 1–15. https://doi.org/10.1002/fsn3.4145 

 

Find Out More

If you’d like more information about HarkePlus RemindPro, please contact Shilpa Mistry, Head of Pharma UK & Ireland.

Cosmospheres® from Omya

As consumer demand for innovative and sustainable personal care products continues to grow, formulators are constantly seeking ingredients that can enhance product performance while providing an attractive and engaging user experience. This is where Omya’s Cosmospheres® come in, offering a versatile, biodegradable solution that meets both functional and aesthetic needs across a range of formulations.Continue reading

Downstream Process Of Amorphous Solid Dispersion

At Making Pharma 2024, Shilpa Mistry – our Head of Pharma across UK & Ireland – showcased some powerful ingredients for amorphous solid dispersions (ASDs). Let’s take a look at what Shilpa covered in her presentation.

The Essence of Amorphous Solid Dispersions

Shilpa’s presentation delved into the critical aspects of ASDs, which enhance drug solubility and bioavailability – ideal for drugs with poor water solubility. She highlighted the innovative use of excipients such as HPMCAS (Shin-Etsu AQOAT®), a cellulose derivative noted for its effectiveness in preventing drug recrystallisation during formulation. This is particularly significant in ensuring the stability and efficacy of pharmaceutical products.

Advanced Techniques and Excipient Grades

The talk focused on two primary techniques for creating ASDs: solvent methods and hot melt extrusion, which help achieve desired solubility and stability in pharmaceutical products.

Shilpa introduced various grades of HPMCAS from Shin-Etsu, including fine (F-Grade), mid-particle (MP-Grade), and granular (G-Grade), which offer tailored dissolution profiles to meet specific formulation needs.

Shilpa detailed the unique properties of these grades, such as varying particle sizes and solubility characteristics, which can significantly influence the downstream processing of pharmaceuticals. Each grade is designed to dissolve at different pH levels, allowing formulators to fine-tune the release profiles of active pharmaceutical ingredients.

Practical Applications and Case Studies

One of the highlights of Shilpa’s presentation was a case study on the use of HPMCAS in spray drying processes. This technique involves dissolving both the drug and polymer in a common solvent, followed by spray drying to achieve the amorphous dispersion. Shilpa discussed the optimisation of this process, focusing on achieving the right powder density and particle size to enhance the drug’s bioavailability.

Shilpa also illustrated the impressive results of roller compaction techniques on ASDs. She demonstrated how the AQOAT® HPMCAS grades from Shin-Etsu can improve the bulk density and flow properties of pharmaceutical powders, enhancing the manufacturability and efficacy of final dosage forms.

Critical aspects of ASDs is the stability and the choosing the right excipients to improve the overall stability ADSs in a tablet formulation. Shilpa looks at the tablet formulation and the stability of ASDs. So using the right filler binder is key. In this presentation she talks about low hydroscopic excipients with dual functionality (disintegrate and binder)  like L-HPC  which is critical in the tablet formulation.

More Information

To find out more about the application studies discussed here, to request samples of AQOAT® HPMCAS and L-HPC grades from Shin-Etsu, and to talk about your specific formulation needs, please do not hesitate to contact Shilpa Mistry at smi@harke.com.