We are pleased to share new testing data released by Sinerga for two of their skin and hair care actives, Azeloglicina® and Trealix®. The new data highlights how these two multifunctional ingredients continue to prove their value.
Whether you’ve been formulating with Azeloglicina® and Trealix® for years, or they’re brand new to you, you’ll find all the key details about both, including the new data released from Sinerga, in this blog post.
Azeloglicina® – Brightening, Balancing, Protecting
Azeloglicina® is a patented compound of azelaic acid and glycine. It is a stable, water-soluble, non-irritating active that delivers the benefits of azelaic acid while providing added moisturisation and elasticity, as well as enhancing skin tolerance.
Azeloglicina® helps to regulate sebum, improve skin radiance, prevent and correct hyperpigmentation of different origins, and soothe irritation. It also supports scalp and hair health by inhibiting 5α-reductase and reducing inflammatory markers linked to hair loss.
New testing data
Highlights from Sinerga’s recent testing of Azeloglicina® include:
- Tyrosinase inhibition: Up to 89% inhibition within minutes, confirming its strong depigmenting power.
- Sebum normalisation: Up to -31% reduction in sebum levels on the T-zone after three weeks.
- In vivo radiance: Significant improvements in skin brightness across Caucasian and Asian volunteers, outperforming benchmarks like kojic acid and arbutin.
- Dark spot reduction: Visible improvements in UV-induced, age-related, post-acne, and melasma-related hyperpigmentation in as little as four weeks.
- Hydration and elasticity: Measurable increases in both parameters, supporting a plumper, smoother complexion.
- Hair loss relevance: Inhibition of 5α-reductase expression (-53%) and DHT production, as well as anti-inflammatory effects through IL-1α reduction.
Key applications
- Dark spot and radiance treatments
- Anti-acne and oily skin care
- Anti-aging products for mature greasy skin
- Illuminating primers and multifunctional make-up
- Anti-hair loss scalp care
Trealix® – Complete Hydration & Cellular Health
Trealix® is a complete hydrating and regenerating ingredient for skin, scalp and hair, combining trehalose (the ‘sugar of life’) with hydrolysed vegetable proteins to offer both humectant and barrier-supporting properties. It works in two ways:
- Boosting water content inside skin and hair.
- Reducing trans-epidermal water loss (TEWL) with a film-forming effect.
Trealix® also promotes autophagy, a natural cellular recycling process that declines with age, helping to preserve healthy cell function. It is COSMOS-approved and preservative free, with a Natural Origin Index of 1.
New testing data
Highlights from Sinerga’s recent testing of Trealix® include:
- Instant hydration: +17% skin hydration in just one minute, with effects lasting at least an hour.
- Long-lasting results: +65% skin hydration after four weeks, with benefits persisting up to six days after stopping use.
- Barrier repair: Up to -15% TEWL reduction, demonstrating a strong film-forming effect.
- Hydration in rinse-off: Increases water content (+16%) and reduces TEWL (-7%) even in cleansing formulations.
- Hair hydration: Improves water content by +12.5% after four leave-on applications.
- Benchmark comparisons: Significantly more effective than other market hydrating agents.
Key applications for Trealix®
- Face and body moisturisers
- Revitalising creams for dry, reddened, or stressed skin
- Scalp serums, essences, and masks
- Shampoos and conditioners
- Cleansers with added hydration
Ready to Formulate?
Azeloglicina® and Trealix® offer formulators multifunctional solutions backed by proven efficacy, from skin brightening and sebum control to deep hydration and cellular health.
If you’d like to learn more about these ingredients, see more from the latest testing data, or request samples for your next formulation, please get in touch with the team at HARKE UK & Ireland.
